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Super Critical Fluid Extraction: Its Wide Range Of Applications
09.14.17

Super Critical Fluid Extraction: Its Wide Range Of Applications

Among the different extraction techniques used, supercritical fluid extraction (SFE) is one of the oldest and the most used separation technique. The use of supercritical fluids in the extraction of volatile components has increased during the last two decades because of its higher efficiency compared to other extraction methods.

Carbon dioxide (CO2) is the most widely used supercritical fluid. This is because CO2 is cheap, chemically inert, non-toxic, non-flammable and readily available at high purities and at low costs. Besides, the critical point of CO2 is easily accessible (critical temperature 31°C and critical pressure 74 bar) allowing the fluid to be used at mild conditions of temperatures (40-60°C) without leaving harmful organic residues.

With advances in process, equipment and product design and realization of the potentially profitable opportunities in the production of high added value products, industries are becoming more and more interested in supercritical fluid technology. It has found applications in many industrial sectors including food, cosmetics, pharmaceutics, materials, chemistry, energy and waste treatment.

Here are a few innovative applications of supercritical fluid extraction across different industries:

  1. Food & Beverage Industry
    One of the methods to improve the flavor of a beer is to enhance the intensity of the hops. Supercritical CO2 hop-oil extraction enables to obtain hop oil extracts with high concentrations and better quality.
    The association of high blood cholesterol levels with heart diseases is the motivating factor in recent works on the reduction of cholesterol levels in consumed meals that include meats, dairy products and eggs using supercritical fluids.
  2. Pharmaceutical Industry
    Among the varied extracts obtained from plants; antioxidants, phytosterols, or even the carotenes, which are used in the pharmaceutical sector, can be easily extracted using supercritical CO2.
    Supercritical fluids are utilized for the production of fine powders, in particular for the formulation of active principles. Pierre Fabre Laboratories (France) have developed the production of fine powders by supercritical CO2 and they were awarded the Pierre Potier 2009 “Innovation in chemistry for sustainable development” for its Formulplex process. This process uses supercritical fluids to increase the bioavailability of active principles.
  3. Medical Cannabis Industry
    Supercritical CO2 extraction of cannabis oil is gaining momentum in the USA as the process gives concentrate makers the ability isolate, capture and scientifically understand the medical effects of more elusive cannabinoids besides THC and CBD. 
  4. Wood Industry
    Superwood (Denmark) has industrialized the impregnation of wood with fungicides dissolved in supercritical CO2 ensuring a lack of mold, avoiding long baths and saving substantial amounts of fungicides.
  5. Textile Industry
    Conventional textile dying methods pose ecological and economical challenges. This issue can be tackled by using supercritical CO2 as an alternative solvent. FeyeCon (Holland), have been successful in the field of supercritical CO2 dying (DyeCoo process) which has been widely acknowledged and grown steadily since its inception.
  6. Energy production
    Extremely promising developments in the areas of liquefaction and gasification of biomass from agricultural wastes in subcritical and supercritical water has opened up the access to unique and sustainable energy sources.

At Cybernetik Technologies, we have developed completely customizable, state of the art and cost effective SFE systems that match international standards and help businesses in reducing batch times compared to traditional solvent based extraction processes, lower operating costs and achieving higher product purity.

Watch this video to get a closer look at the SFE systems developed at Cybernetik Technologies.

21.04.20

Equipment Validation For Pharmaceutical Equipment

Equipment Validation For Pharmaceutical Equipment

How Important is Equipment Validation in the Pharma Industry? Disasters often stir humankind into constructive action. It was in the wake of the infamous “Contergan Scandal” that Good Manufacturing Practice (GMP) evolved in the United States in 1963 [1]. And, the issue of sterility in the parenteral market made two Food and Drug Administration (FDA) officials put forth the concept of validation in 1979 [2]. Pharma products have a direct impact on the health of the consumers. Ensuing quality of products is, therefore, a top priority for regulators. Dosage strongly impacts the percentage of the drug that reaches the site of action. Therefore, each batch of manufactured drugs must be of the same quality [3], meaning consistency is of paramount importance. Equipment Validation documents evidence that a piece of equipment conforms with the required standards across all stages [4]. GMP ensures that quality is an integral part of a product and not merely tested in it [5]. Equipment validation is a component of GMP which guarantees that the equipment maintains the required standards and, as a result, consistently provides products of the necessary quality [5]. Cybernetik Technologies has successfully validated and delivered multiple pieces of equipment for the pharmaceutical industry. Our technicians engage with clients throughout the equipment validation process, while conforming with the US FDA Part 211 and Part 11, EU Annexe 11, and cGMP standards, and also drafting the necessary documents. When the validated equipment is part of a larger process, the validation documents play another key, although indirect, role – that of rapid error detection. If the process output is not as expected, technicians need to pin point the error. They can safely rule out equipment defect because it is already validated [6].   Equipment Validation for Pharma Industry Equipment Cybernetik Technologies implements validation for pharmaceutical equipment […]

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18.07.18

Hiring: Technical Proposals & Marketing Engineer

Hiring: Technical Proposals & Marketing Engineer

Get in touch if you fulfill the following requirements and wish to work on exciting projects in industrial automation.

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29.06.20

Ready-to-Eat (RTE) Food Manufacturing Process

Ready-to-Eat (RTE) Food Manufacturing Process

Safety: A Paramount Necessity Tertiary Food Processing delivers Ready to Eat (RTE) foods and Heat to Serve foods [1]. RTE foods include instant snacks and soups, ready meals, baked goods, instant/breakfast cereals, meat products and the like [2]. Young people in the 18-35 age-group are the most active consumers of RTE foods [2]. Safety is at the core of all processes for manufacturing RTE foods. This is because they are not processed any further [3] – their hygiene has to be ingrained in their processing. Regulatory bodies prescribe strict standards for operators across the food supply chain. For example, the Food Safety and Standards Authority of India (FSSAI) mandates a documented Food Safety Management System (FSMS) plan for every operator. FSMS plan includes Good Manufacturing Practices and Good Hygienic Practices specific to the sector [4]. Apart from safety, these standards ensure nutritional value of foods. Such standards establish what foods can and cannot contain as well as what are the minimum and/or maximum limits of ingredients they can contain. This, they do by: • Restricting the amount and type of natural and synthetic contaminants including microbes, pesticide/insecticide residues, and metal, antibiotic, and crop contaminants [4]. • Laying down guidelines for which food additives can be included and in what quantity [4]. • Instituting norms for packaging, labeling, and advertisement claims [4]. • Capping the industrial trans-fat content in foods for them to qualify as trans-fat-free [5].   RTE Manufacturing Process Safety is of course the core principle for RTE foods manufacturing. The process must also be rapid, energy efficient, and ergonomic while developing the required food flavor and texture. Following are the general stages in manufacturing RTE foods: • Unloading & Transport: Unloaded raw materials are transported to the location of the cleaning equipment. • Cleaning: Removes dirt, dust, mud, […]

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